The effects on quality of life appear within 3 to 4 weeks, but maximum benefits take longer. Testosterone has a range of effects on the male body. This review attempts to determine, based on published studies, the temporal evolution of the effects induced by testosterone replacement therapy from its first manifestation until maximum effects are reached. It should be noted that almost none of the studies cited were specifically designed to evaluate the temporal evolution of effects.
Some studies measure the effects of testosterone only after 3 months (3) and, in particular, the effects on libido and erections have occurred long before this time period (14, 6). We noticed significant differences in the onset of the effects of testosterone. The effects on libido and other psychological variables and the effects on the vasculature occur quite rapidly. It is quite possible that these effects are not mediated by the classic androgen receptor, but by other mechanisms, such as effects on membranes (6,.
In addition, the effects on erection occur quite rapidly and can be explained in part by non-genomic effects on the vascular erectile tissue of the penis (8). The first physical changes you are likely to notice are that the skin becomes slightly thicker. and fat. Your pores will enlarge and there will be more oil production.
You'll also notice that the smells of sweat and urine will change and that, in general, you may sweat more. You can develop acne, which in some cases can be annoying or severe, but can usually be controlled with good skin care practices and common acne treatments. Some people may need prescription medications to control acne; talk to your healthcare provider about this. Acne severity usually peaks during the first year of treatment and then gradually improves.
Acne can be minimized by using an adequate dose of testosterone that avoids excessively high levels. Some physical and psychological changes can start right away for many users. Some physical effects may include thickening of the skin (which can also affect the feeling you feel when you touch it), increased oil and sweat production and, in some cases, acne. Remember that a sudden increase in your testosterone level from what your body is used to can be similar to puberty.
Obviously, these effects are directly related to testosterone and not to its flavoring product E2, as was later confirmed in a placebo-controlled trial in which an aromatase inhibitor was combined with the administration of testosterone in hypogonadal men. After the first injection of testosterone, many people may begin to feel an increase in energy and mood, although the full effects usually take a while. Before doing any laboratory tests, let your doctor and the laboratory staff know that you are receiving a testosterone injection. Testosterone is a male sex hormone responsible for the development and functioning of the male sexual organs and for typical male characteristics. In addition to analyzing the onset of the effects of testosterone treatment in hypogonadal men, it would also be possible to analyze the onset of symptoms of testosterone deficiency in patients receiving androgen deprivation therapy (ADT), the standard treatment for men with advanced prostate cancer.
Injectable testosterone comes as a solution (liquid) to be injected into a muscle by a doctor or nurse in an office or clinic. Testosterone replacement therapy, or TRT, involves giving supplemental testosterone to people with low levels. Read on for an overview of some of the most likely things you can expect in your first weeks and months with testosterone. The length of the spectrum of effects of testosterone can vary considerably, as the actions of testosterone are exerted through a cascade of many different pathways.
If your menstrual periods have stopped due to testosterone treatment, be sure to report any recurrence of bleeding or spotting to your healthcare professional, who may request an ultrasound or other tests to ensure that the bleeding is not a symptom of an imbalance of the lining of the uterus. This is a systematic analysis of the temporal evolution of the spectrum of the biological effects of testosterone in the different target systems. Transgender men can become pregnant while taking testosterone, so if you remain sexually active with someone who is capable of producing sperm, you should always use birth control to avoid an unwanted pregnancy. Testosterone will cause the vocal cords to thicken, making the voice sound more masculine.
The temporal evolution of the spectrum of effects of testosterone shows a considerable variation, probably related to the pharmacodynamics of the testosterone preparation. Testosterone may reduce the ability to become pregnant, but it doesn't completely eliminate the risk of pregnancy.
