What Age is Best for Testosterone Replacement Therapy?

Testosterone Replacement Therapy (TRT) is a treatment option for men who experience low testosterone levels. Learn more about the best age for TRT.

What Age is Best for Testosterone Replacement Therapy?

Testosterone Replacement Therapy (TRT) is a treatment option for men who experience low testosterone levels. While it is generally given to men over 50 years of age, it can be beneficial for men of any age who need it. Women also produce testosterone in their ovaries, but they don't start losing it until they reach menopause, usually between 45 and 55 years old. The American College of Physicians released new guidelines stating that older men whose testosterone levels have declined should only receive a testosterone substitute to treat sexual dysfunction.

Meanwhile, research has shown that testosterone treatment had little or no effect on cognition in older men without age-associated cognitive decline. This review aims to analyze the possible benefits and complications of testosterone replacement therapy in men over 60 years of age. In previous years, the prevalence in women over 65 years of age led to a significant amount of research on the benefits and health risk factors related to estrogen replacement therapy. However, the effects of testosterone replacement therapy in men over 60 years of age remain poorly studied.

Clinical trials have reported that comorbidities, such as obesity and diabetes mellitus, were relatively high in clinical trials with testosterone. It's important to note that having low testosterone levels (LoWT) alone doesn't always indicate that you need TRT. The clinical trials analyzed in this review were selected based on a duration of testosterone replacement therapy of no less than 6 months, with several follow-up periods, and in which statistically significant increases in testosterone levels were reported at the start of treatment and throughout the clinical trial period. Lower than normal testosterone levels can be found in approximately 45% of all men over 45 years of age.

Men begin to lose between one and two percent of testosterone a year once they reach their 30s, so when they reach their 50s and 60s, they may begin to experience signs of low testosterone levels. Even men under 30 can also experience low testosterone levels, according to Healthline. Because men continue to produce testosterone throughout their lives (many men are fertile even after age 80), TRT can be useful for men regardless of their age. Lower testosterone levels are part of the aging process, but the good news is that you don't have to live with it. Ultimately, the best age for TRT is any age at which you personally need it.

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