Testosterone replacement therapy (TRT) is a widely used treatment for men with symptomatic hypogonadism. It is known to offer a range of benefits, such as increased libido and energy levels, beneficial effects on bone density, strength and muscles, as well as cardioprotective effects. However, it is important to be aware of the potential long-term effects of TRT. TRT can cause acne or other skin reactions, and stimulate non-cancerous prostate growth (benign prostatic hyperplasia).
It is contraindicated in men with untreated prostate and breast cancer, and men receiving TRT should be monitored for side effects such as polycythemia, peripheral oedema, and heart and liver dysfunction. Many longitudinal studies have investigated the relationship between endogenous testosterone levels and subsequent risk of prostate cancer, but have found no association. Changes in waist circumference have been observed in hypogonadal men who were normal weight, overweight or obese at the start of the study, treated with or without testosterone therapy. Testosterone replacement therapy is a reasonable treatment option that is often considered for men with low testosterone levels and symptoms of hypogonadism.
However, one of the major risk factors associated with testosterone supplementation is its effect on the prostate. Millions of American men use a prescription testosterone injection or gel as forms of TRT to restore normal male hormone levels. Long-term treatment of hypogonadal men with testosterone results in substantial and sustained weight loss. It offers men who are feeling unwell a chance to feel better, but that quick fix could distract attention from unknown dangers in the long term.
Side effects reported in children who have been in contact with these drugs include genital enlargement, premature pubic hair growth, increased self-stimulation, and aggressive behavior. While older men receiving testosterone therapy have an increase in overall prostate size, this increase in size is no different from the increase in prostatic hypertrophy seen in older men who do not receive testosterone therapy. Pharmaceutical companies that manufacture testosterone replacement drugs market their products to a large extent, promising men greater vitality, strength, sexual desire and a better quality of life in general. Accidental exposure in boys who live or interact closely with men who use topical testosterone medications is a serious problem. Serious side effects are rare and the most commonly reported side effects in clinical trials were mostly mild. By adding liraglutide to lifestyle changes, metformin and testosterone therapy stimulates erectile function in obese diabetic men with overt hypogonadism.
Leave a Comment