The effects on quality of life appear within 3 to 4 weeks, but maximum benefits take longer. Testosterone has a range of effects on the male body. This review attempts to determine, based on published studies, the temporal evolution of the effects induced by testosterone replacement therapy from its first manifestation until maximum effects are reached. It should be noted that almost none of the studies cited were specifically designed to evaluate the temporal evolution of effects.
Some studies measure the effects of testosterone only after 3 months (3) and, in particular, the effects on libido and erections have occurred long before this time period (14, 6). We noticed significant differences in the onset of the effects of testosterone. The effects on libido and other psychological variables and the effects on the vasculature occur quite rapidly. It is quite possible that these effects are not mediated by the classic androgen receptor, but by other mechanisms, such as effects on membranes (6,.
In addition, the effects on erection occur quite rapidly and can be explained in part by non-genomic effects on the vascular erectile tissue of the penis (8). Sexual interest usually begins to improve after 3 weeks and stabilizes around 6 weeks. Effects on mood, such as a reduction in depressive symptoms, may begin to appear within this period. Initial changes in fat mass, lean body mass, and muscle strength become apparent.
Improvements in quality of life continue to occur, including mood stabilization. Lipid changes also begin around this time, and their maximum effects take several months. It may take a few weeks before you start to notice differences in your body and mood once you start taking TRT. The time it takes varies from person to person. For the therapy to take full effect, healthcare providers usually wait 30 days after starting TRT to check testosterone levels.
As you move toward the middle phase, many people begin to notice more apparent changes. Improved mood and increased energy levels become more consistent, and some people may experience improved sexual function. For those using testosterone cypionate, the results may be more noticeable during this period. This phase marks a turning point where the benefits of TRT begin to manifest more clearly.
According to research, it can take two to six weeks for testosterone injections to start to work. Studies show that Nebido testosterone injections can work within three weeks of the first dose and effectively improve mood and energy levels. The injections tend to work faster and show noticeable changes, such as better energy or libido, in 2 to 3 weeks. Testosterone levels peak 48 to 72 hours after injection, which can cause peaks in the middle of the week and drops at the end of the week.
Some people naturally metabolize testosterone faster than others, meaning their bodies may need higher or more doses. frequent to maintain optimal levels.
