Can testosterone therapy promote youth and vitality? Testosterone therapy can help reverse the effects of hypogonadism, but it's not clear if it's testosterone. Testosterone therapy can help reverse the effects of hypogonadism, but it's not clear if testosterone therapy would benefit older men who are otherwise healthy. But can testosterone replacement therapy help treat heart disease? The results of the studies are mixed. In small studies conducted in the early 2000s, it was found that men with heart disease who underwent testosterone therapy experienced only slight improvements.
Some managed to increase walking distance by 33 percent. Another study found that hormone therapy only widened healthy arteries, but had no effect on angina pain. A larger and more recent study, involving 83,000 men, found that men whose testosterone levels returned to normal were 24 percent less likely to have a heart attack and 36 percent less likely to have a stroke. Increased longevity and an aging population will increase the number of men with late-onset hypogonadism.
It's a common condition, but it's often underdiagnosed and undertreated. The indication for treatment with testosterone replacement therapy (TRT) requires the presence of a low level of testosterone and the presence of symptoms and signs of hypogonadism. While controversy remains over the indications of testosterone supplementation in older men due to the lack of large scale, long-term studies evaluating the benefits and risks of testosterone replacement therapy in men, reports indicate that TRT can produce a wide range of benefits for men with hypogonadism, including improved libido and sexual function, bone density, muscle mass, body composition, mood, erythropoiesis, cognition, quality of life and cardiovascular diseases. Perhaps the most controversial area is the question of risk, especially the potential stimulation of prostate cancer by testosterone, although there is no evidence to support this risk. Other possible risks include worsening symptoms of benign prostatic hypertrophy, liver toxicity, hyperviscosity, erythrocytosis, worsening of untreated sleep apnea, or severe heart failure.
Despite this controversy, testosterone supplementation in the United States has increased considerably in recent years. The doctor should discuss with the patient the potential benefits and risks of TRT. The purpose of this review is to analyze what is known and what is not known regarding the benefits and risks of TRT. Testosterone is the main sex hormone in men.
It is essential for the development of male growth and male characteristics. A new study reveals that an increase in the male hormone testosterone helps improve body composition, even in men with testosterone levels close to the lower limit of normal. The increase in testosterone, the male hormone, helps improve body composition, even in men with low testosterone levels. Physicians and researchers have different opinions regarding the efficacy of testosterone replacement therapy. The updated review indicates that supplementation with the hormone testosterone positively influences several aspects, such as sexual function, bone health, muscle strength, mood (especially to reduce depression) and vascular endothelial function.
The side effects of the medication, such as nausea, vomiting and headache, were no different from those previously reported. Testosterone replacement therapy aims to restore hormone levels to the normal range of young adults and, in theory, should approximate the natural endogenous production of the hormone, produce and maintain physiological serum concentrations of the hormone and its active metabolites without major side effects or safety problems and, most importantly, alleviates the symptoms they suggest a hormone deficiency. Some of these signs and symptoms may be due to other factors, such as medication side effects, obstructive sleep apnea, thyroid problems, diabetes, and depression. Most importantly, are the beneficial effects on patients' mood, energy levels and sense of well-being, sexual function, lean body mass and muscle strength, erythropoiesis and bone mineral density (BMD), cognition, and some benefits on cardiovascular risk factors.
The results of randomized placebo-controlled trials on the effect of testosterone on quality of life and depressed mood were inconsistent between trials and inaccurate. In clinical trials on the effect of testosterone on bone density, increases in bone density were detected. of the spine and hip. Testosterone replacement may be effective in reversing age-dependent changes in body composition and associated morbidity.
However, the correlation with bioestradiol, whose levels decrease in older men, was even greater, suggesting that part of the effects of androgens on bones are at least partially, indirect, mediated by their aromatization.
