Like HCG, Clomiphene Citrate (CC) was originally designed for female infertility. Approved by the FDA in 1967, it has since become a low-cost generic drug. Central hypogonadism is a clinical condition characterized by sexual symptoms and low serum testosterone levels, due to impaired function of the hypothalamus or the pituitary gland.
Testosterone replacement
therapy (TRT) is the standard treatment for hypogonadism, but it has some drawbacks.TRT is not a good option for men who want to preserve fertility, or for men with (high risk of) prostate cancer, polycythemia, thrombophilia and serious cardiovascular diseases. In this review, we discuss alternative treatments for central hypogonadism. If there are reversible causes, non-pharmacological interventions may be therapeutic. Gonadotropins are a good alternative to TRT when you want to obtain fertility in the near future, although require frequent injections.
Clomiphene citrate and tamoxifen appear to be a safe alternative for the treatment of functional central hypogonadism in men, as several studies reported a significant increase in testosterone levels with these drugs. However, its use is not indicated on the label and there is insufficient data supporting the efficacy of clomiphene citrate and tamoxifen on symptoms of hypogonadism. For this reason, clomiphene citrate and tamoxifen should not be used in routine clinical practice to treat sexual symptoms in men with central hypogonadism. Taking magnesium as a supplement has been shown to increase total and free testosterone levels.
This can work for both sedentary individuals and athletes. People who exercise had higher increases in testosterone. Bajic and Parekh, testosterone replacement therapy should be used in patients who have symptoms of testosterone deficiency, not to increase testosterone in patients with normal levels.
